Our services
Recombinant proteins
Using its extensive technical expertise, Angel is able to provide a highly integrated array of services to support the development of a biopharmaceutical protein product. Services offered range from process development and scale-up through to cGMP manufacture.
Angel can produce recombinant protein products from microbial or mammalian cell sources to provide material for preclinical through to Phase III clinical trials and commercial production.
Process development fermentation and downstream processing
Angel’s GMP bioreactors range in size up to 750L, with capabilities to develop and optimise processes to meet our client’s needs. We have a choice of cell harvesting techniques at our disposal including the use of TFF membrane systems for ultrafiltration and diafiltration, and the use of centrifugation and ultracentrifugation techniques.
Cell disruption can be performed using automated, mechanical cell disruption and we use pharmacia chromatography systems for automated purification.
Through optimisation of these processes, we are able to optimise protein yields, reducing the costs and timelines for your recombinant protein production.
Analytical method development
Angel offers a wide range of equipment and expertise to develop product specific analytical assays to test the purity and concentration of your product. These include:
- reverse phase HPLC;
- size sxclusion HPLC;
- SDS-PAGE;
- tangential flow filtration/diafiltration;
- isoelectric focussing;
- spectrophotometry;
- peptide mapping;
- rndotoxin determination;
- ELISA;
- cell based potency assays; and
- bioburden testing.
Areas of expertise
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Our facilities
Angel's MHRA licensed facilities are located at Pentlands Science Park on the outskirts of Edinburgh.
